Obesity can have adverse effects on the brain, as per a recent study published in the Journal of Alzheimer’s Disease. The study found that obesity can lead to symptoms similar to those seen in Alzheimer’s disease, such as cortical thinning in specific areas of the brain.
The study is the first to compare the patterns of brain shrinkage in Alzheimer’s and obesity directly. The findings show that obesity and Alzheimer’s disease can cause grey matter shrinkage in the same parts of the brain, including the right temporoparietal cortex and left prefrontal cortex.
Moreover, obesity is associated with several risk factors for Alzheimer’s disease, including high blood pressure, diabetes, and inflammation. These conditions can damage the blood vessels in the brain, leading to reduced blood flow and oxygen supply, which can contribute to the development of cognitive impairment and dementia. In fact, some studies have suggested that the risk of developing Alzheimer’s disease may be up to three times higher in individuals with obesity compared to those with a healthy weight.
However, the good news is that weight loss may be a potential strategy for reducing the risk of Alzheimer’s disease in obese individuals. Studies have shown that losing weight can improve insulin sensitivity, reduce inflammation, and improve blood vessel function, all of which can have positive effects on brain health. Furthermore, a healthy diet and regular exercise may also help to reduce the risk of Alzheimer’s disease by promoting brain health and reducing the impact of risk factors associated with obesity.
Decreasing weight in mid-life may reduce the risk of dementia, as cortical thinning might be a potential risk mechanism for Alzheimer’s disease. The study also highlights the importance of addressing obesity as a multisystem disease that affects not only the heart, lungs, stomach, and colon but also the brain.
